The expansion study is designed to understand how our responses to immune and inflammatory stressors, such as infections and vaccines, can influence our health and well-being over time.

People who might appear similar in overall health status can often respond very differently to the same stress triggers – and these differences can shed light on future health trajectories.

We plan to serially measure antibodies and other factors that can represent health trajectories that diverge over time. We are taking this approach to uncover scientific clues and make new discoveries that may guide us on how to maximize recovery from stress and improve longer-term health for all.

When our team founded the original CORALE study in March 2020, we hoped the pandemic might last a year or less. We focused our studies on illness susceptibility and resistance, and we built resources to support serial assessments, including repeat antibody testing, for up to 2 years.

Recognizing the persistent effects of the pandemic, our team is now committed to studying how individuals and communities can recover from the pandemic and maintain health resilience over the longer term. We have now built resources that can support more frequent assessments, including repeat antibody testing, for up to 5 years or longer as needed.

For this reason, this expansion study will minimize any added time commitment for original CORALE study participants while allowing the option for more frequent assessments, including antibody testing, for a longer period of time.

Due to operational logistics, the expansion study is currently only open for enrollment for employees and patients who are directly affiliated with the Cedars-Sinai Medical Center and associated medical networks. A limited number of enrolled participants who have moved out of the Los Angeles area may continue participation through remote health surveys and remote biosampling collection kits.

Our recent scientific reports are listed here and will be updated as new information is generated.

For additional questions about the study, you may email contact@embarc-study.org.